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Gangliosides Analysis Service

Gangliosides are a large family of complex lipids that are components of neural cell membranes that are abundantly found in the brain. A ganglioside is a molecule composed of a glycosphingolipid with one or more sialic acids linked on the sugar chain. Gangliosides are structural components of cell membranes, with the two hydrocarbon chains embedded in the plasma membrane and the oligosaccharides located on the extracellular surface, where they provide points of recognition for extracellular substances or surface molecules of the neighboring cells. The oligosaccharide groups act as distinguishing surface markers that play important roles in cell–cell recognition, adhesion, and signaling.

Gangliosides Analysis Service Figure 1. Structure of GM1 ganglioside

Gangliosides are shown to provide a neuroprotective role by promoting neural development in the neonate, and are involved in memory and learning. However, the mechanism is not very clear. Some believe that ganglioside can protect the cell from harsh conditions, such as low pH and degradative enzymes, in the extracellular environment. They were shown to help cells interact with extracellular matrices and other cells. Gangliosides are also related to cancer and Alzheimer’s disease. During aging and in some neurodegenerative diseases, the profile of Ganglioside pattern. Pronounced alterations in ganglioside profiles have been found in the Alzheimer's, Parkinson's, Huntington's disease, HIV 1-related dementia, and lysosomal storage diseases.

So far, mass spectrometry (MS) has been extensively employed to study gangliosides.

GC–MS/MS platform enable quantification of ganglioside species. The results are widely used for investigating the relative changes in ganglioside concentrations, and potential biomarker discovery. GC–MS/MS techniques serves as a powerful analytical tool for identification and quantification of gangliosides. Creative Proteomics has established sensitive, reliable, and accurate GC-MS/MS method for quantification of ganglioside species.

Feature and Advantage of Ganglioside Analysis

Cutting-edge facilities
Reliable & Reproducible
Comprehensive analysis of ganglioside analysis

Platform

GC-MS/MS

Sample Requirment

Normal Volume: 200 mL plasma; 100mg tissue; 2e7 cells
Minimal Volume: 50 mL plasma; 50mg tissue; 5e6 cells

How to place an order:

Ordering Procedure

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Lipidomics Sample Submission Guidelines

Download our Lipidomics Sample Preparation Guide for essential instructions on proper sample collection, storage, and transport for optimal experimental results. The guide covers various sample types, including tissues, serum, urine, and cells, along with quantity requirements for untargeted and targeted lipidomics.

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Metabolomics Sample Submission Guidelines

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

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